FWIW, my defensive setup uses the following essences:
4x Greater Morale
4x Greater Critical Defence
4x Greater Tactical Mitigation
2x Greater Physical Mitigation
10x Supreme Physical Mastery.
I sit at 50k mastery (with food and scrolls), 30% crit chance, mitigations are capped with scrolls (so I sit at 58% in my raid build) and also have crit defence at 56%. All this with 16.9k morale unbuffed.
Clearly to get a tanky build as outlined above you need to sacrifice dps, but it's not horrendous if you are smart about it.
Wulfhram (Hunter), Boborrin (Champ), Garrth (Captain) assorted others