I would add that I am now in the mind-set of de-buff before DPS in my solo roaming unless I expect to burn through them almost before the stun wears out.

I used to be like an earlier poster and think that time taken to de-buff was better spent actually doing DPS but having tested for some time and having spoken to those I fight on the other side at times, I have reverted to always getting off Savage Fangs, Fleas and Snap ASAP in fights.

It is hard to state an exact rotation as it can vary on the class you face but in general for me (in Shadow) it is SP > Pounce > Maul > Cripple > Savage Fangs > Eye Rake > Snap > Fleas > DPS time! You should now have them well de-buffed (and many freeps I have spoken too particulaly hate Fleas and Snap being on them) and barring resists/avoids also have 2 bleeds ticking away as well. After that it is really about using Maul/Claws/Rend and staying behind them all the time that wins fights.

If they are a minstrel then Throat Rip comes after Eye Rake. It can be worth using Rabid on Champs you expect to go popping CD's but tbh they often have so much power it doesn't help ^^

I am back out of favor with Flayer at the moment, preferring to slot Element of Suprise, (which I have previously dissed) the defensive benefits do not outweigh the DPS nerf in my opinion, I run 3 crit, 1 crit protection, HfP2 and DfP2